Avoiding bias from weak instruments in Mendelian randomization studies

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ID: 289991
2011
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Abstract
Background Mendelian randomization is used to test and estimate the magnitude of a causal effect of a phenotype on an outcome by using genetic variants as instrumental variables (IVs). Estimates of association from IV analysis are biased in the direction of the confounded, observational association between phenotype and outcome. The magnitude of the bias depends on the F-statistic for the strength of relationship between IVs and phenotype. We seek to develop guidelines for the design and analysis of Mendelian randomization studies to minimize bias.
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openalex_W2127768736 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Stephen Burgess, Simon G. Thompson
Journal International Journal of Epidemiology
Year 2011
DOI
10.1093/ije/dyr036
URL
https://doi.org/10.1093/ije/dyr036
Keywords Keywords not found

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