Structure and function of matrix metalloproteinases and TIMPs

Clicks: 8
ID: 289964
2006
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Abstract
Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology.
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openalex_W2002771508 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hiroyuki Nagase, Robert Visse, G MURPHY
Journal cardiovascular research
Year 2006
DOI
10.1016/j.cardiores.2005.12.002
URL
https://doi.org/10.1016/j.cardiores.2005.12.002
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