Relaxing the Rule of Ten Events per Variable in Logistic and Cox Regression

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ID: 289853
2006
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Abstract
The rule of thumb that logistic and Cox models should be used with a minimum of 10 outcome events per predictor variable (EPV), based on two simulation studies, may be too conservative. The authors conducted a large simulation study of other influences on confidence interval coverage, type I error, relative bias, and other model performance measures. They found a range of circumstances in which coverage and bias were within acceptable levels despite less than 10 EPV, as well as other factors that were as influential as or more influential than EPV. They conclude that this rule can be relaxed, in particular for sensitivity analyses undertaken to demonstrate adequate control of confounding.
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openalex_W2130373985 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eric Vittinghoff, Charles E. McCulloch
Journal american journal of epidemiology
Year 2006
DOI
10.1093/aje/kwk052
URL
Keywords Keywords not found

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