Interferon-γ: an overview of signals, mechanisms and functions

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ID: 289737
2003
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Abstract
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-γ are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-α, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.
Reference Key
openalex_W2167017590 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kate Schroder, Paul J. Hertzog, Timothy Ravasi, David Hume
Journal journal of leukocyte biology
Year 2003
DOI
10.1189/jlb.0603252
URL
https://doi.org/10.1189/jlb.0603252
Keywords Keywords not found

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