Empirical threshold values for quantitative trait mapping.

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ID: 289503
1994
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Abstract
The detection of genes that control quantitative characters is a problem of great interest to the genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative to maps of genetic markers are now widely used. This paper addresses an issue common to all QTL mapping methods, that of determining an appropriate threshold value for declaring significant QTL effects. An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand. The method is demonstrated using two real data sets derived from F(2) and recombinant inbred plant populations. An example using simulated data from a backcross design illustrates the effect of marker density on threshold values.
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openalex_W2125860227 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gary A. Churchill, R. W. Doerge
Journal current genetics
Year 1994
DOI
10.1093/genetics/138.3.963
URL
https://academic.oup.com/genetics/article-pdf/138/3/963/34601243/genetics0963.pdf
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