Encapsulation of sulfamethazine by native and randomly methylated β-cyclodextrins: The role of the dipole properties of guests.
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ID: 28889
2019
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Abstract
Sulfonamides are preventive and therapeutic agents for certain infections caused by gram-positive and gram-negative microorganisms. In this work the interactions of sulfamethazine, a representative of sulfonamide antibiotics, with two β-cyclodextrin derivatives were investigated at different pH. Results show formation of stable sulfamethazine - β-cyclodextrin complexes and reflect importance of the competition of the hydrogen bonding and electrostatic interactions. The complex geometry formed is affected by the orientation of the pH-dependent dipole moment of sulfamethazine molecule and prolonged prior the sulfamethazine molecule enters into the β-cyclodextrin's cavity. Functionalization of the β-cyclodextrin molecule doesn't affect considerably the complex stabilities, therefore the native β-cyclodextrin molecule looks the simplest and most effective inclusion host to design selective and sensitive tool for sulfamethazine sensing.
| Reference Key |
mohamed-ameen2019encapsulationspectrochimica
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| Authors | Mohamed Ameen, Hiba;Kunsági-Máté, Sándor;Szente, Lajos;Lemli, Beáta; |
| Journal | spectrochimica acta part a, molecular and biomolecular spectroscopy |
| Year | 2019 |
| DOI |
S1386-1425(19)30865-0
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| URL | |
| Keywords | Keywords not found |
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