The Malaria Cell Atlas: Single parasite transcriptomes across the complete life cycle.

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ID: 28728
2019
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Abstract
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
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howick2019thescience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Howick, Virginia M;Russell, Andrew J C;Andrews, Tallulah;Heaton, Haynes;Reid, Adam J;Natarajan, Kedar;Butungi, Hellen;Metcalf, Tom;Verzier, Lisa H;Rayner, Julian C;Berriman, Matthew;Herren, Jeremy K;Billker, Oliver;Hemberg, Martin;Talman, Arthur M;Lawniczak, Mara K N;
Journal Science
Year 2019
DOI
eaaw2619
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