Characterization of encapsulated quercetin in metal alginate hydrogels for drug delivery system

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ID: 285072
2022
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Abstract
Quercetin is an important drug that exhibits antioxidant, anti-cancer, anti-inflammatory, and antiviral effects that has been also used in treating cardiovascular diseases. However, its insolubility, low bioavailability, short biological half-life, and instability pose a problem in delivering it to the body. To improve its bioavailability, this work encapsulates quercetin in metal-alginate matrices consisting of Ca2+, Zn2+ and a combination of the two ions for a site-specific and controlled release. Quercetin-loaded hydrogels were formed via a dropwise addition of quercetin-alginate mixture into the metal bath to afford a yellow-colored spherical hydrogel. Successful encapsulation of quercetin was confirmed by FTIR, TGA, DSC, SEM-EDS, and UV-vis with encapsulation efficiency as high as 92.57±0.31% for the bimetal-alginate system. The drug release profile in physiological pH simulating gastric (pH 1.2) and intestinal (pH 8.2) conditions revealed that most of the drug remains in the hydrogel protected from the harsh acidic condition of the stomach and preferential full release at simulated intestinal fluid (SIF) was observed. The bimetal-alginate matrix showed the most controlled release of drug in SIF. The study reveals the potential of the drug delivery system for efficient oral therapy of quercetin, ensuring a controlled and targeted release in simulated intestinal conditions where absorption into the bloodstream occurs
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persistent_1760654541_68f174cd967f0 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fajardo, Tricia Jan Marie C.
Journal Malay Journal
Year 2022
DOI
DOI not found
URL
https://animorepository.dlsu.edu.ph/etdm_chem/3
Keywords Keywords not found

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