NMR-based serum metabolomic profiling of Filipino colorectal cancer patients towards identification of putative cancer stage markers

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ID: 285052
2025
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Abstract
Colorectal cancer (CRC) in the Philippines poses a significant threat due to the healthcare system having limited screening programs. Survival is dependent on its stage at diagnosis, therefore early detection is key to preventing CRC. Present diagnostic tools are insufficient and have poor patient compliance, while cheaper and noninvasive ones have yet to be developed. Metabolomics can be used to identify relevant biomarkers as the metabolome is the closest description of the phenotype. This study utilized a nuclear magnetic resonance (NMR) spectroscopy-based approach for the metabolomic profiling of serum samples from Filipino CRC patients at different stages and healthy/non-diseased controls. Principal component analysis (PCA), partial least squares-discriminant analysis, (PLS-DA), and orthogonal PLS-DA (OPLS-DA) revealed distinct clustering of CRC versus control. The identified metabolites in CRC are mostly similar across stages—amino acids, lipids, and ketone bodies being the most common. Acetone, 3-hydroxybutyrate, and 2-hydroxybutyrate were found to be significantly upregulated in CRC. Pathway topology analysis identified phenylalanine, tyrosine, and tryptophan biosynthesis as the significantly dysregulated pathway compared to control. These findings aim to add to the understanding of disease etiology and pathogenesis of CRC. Validation of the dysregulated metabolites identified in this study in larger cohorts may lead to the development of novel biomarkers to support diagnosis, prognosis, and treatment strategies for CRC.
Reference Key
persistent_1760654483_68f174932ec1b Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Inquimboy, Ionna H.
Journal Malay Journal
Year 2025
DOI
DOI not found
URL
https://animorepository.dlsu.edu.ph/etdm_chem/27
Keywords Keywords not found

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