Fabrication and characterization of 3D-bioprinted PVA/dECM scaffolds for biomedical applications
Clicks: 3
ID: 284825
2024
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.6
/100
3 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #1,407 of 3,757 articles by views in Malay Journal
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 3,757 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Fabrication of PVA/dECM scaffolds were made to address the lack of bioactive components in existing pure PVA scaffolds. This was done through extrusion bioprinting or 3D printing with the aim to fit biomedical applications. Moreover, the effect of incorporating dECM to the PVA was analyzed in terms of viscosity, surface functional groups, mechanical properties, and swelling capacity. Results from the conducted tests were then correlated to established values in literature to determine its potential biomedical applications. dECM was obtained through an existing decellularization protocol and combined into 15:0, 30:1, 40:3, and 70:9 proportions of PVA/dECM. Each proportion was analyzed under a viscometer to test its printability prior to conducting FTIR, mechanical, and swelling tests. All PVA/dECM proportions were determined to be rheopectic in nature; however, the addition of dECM relatively decreases the overall viscosity of the solution with an approximated 50% decrease in viscosity from 15:0 to 70:9. Incorporating glutaraldehyde, a chemical crosslinker, increased the overall viscosity of the PVA/dECM solution. Aside from this, the increased addition of dECM influenced a decrease in ultimate tensile strength (UTS) and Young’s modulus. These are reflected in the 30.43 MPa and 19.07 MPa UTS values for 15:0 and 70:9 respectively, while 1.59 MPa and 0.49 for Young’s moduli. Conversely, the addition of more dECM promoted an increased ultimate swelling capacity of the PVA/dECM scaffold showing percent increases of 12%, 17%, and 29% from 30:1, 40:3, and 70:9 proportions relative to the 15:0 proportion. These were further verified by the generation of broader peaks among hydrophilic functional groups. Overall, results from all three proportions have the potential of being used in cartilage and soft tissue applications. Conducting additional tests such as anti-bacterial tests, scanning electron microscopy, and in-vitro test methods could help analyze the sterilization, porosity, and effective cell proliferation of fabricated scaffolds. These, along with the conducted study, could help improve and open more doors to 3D printing in the biomedical field.
| Reference Key |
persistent_1760653791_68f171df1ff7d
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Singco, Yvonne L. |
| Journal | Malay Journal |
| Year | 2024 |
| DOI |
DOI not found
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.