Angiogenesis and invasion inhibition of Carmona retusa (tsaang gubat) leaf extract in small cell lung cancer (H69PR in ovo culture)

Clicks: 5
ID: 284700
2025
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #262 of 3,757 articles by views in Malay Journal

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 3,757 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Lung cancer is the leading cause of mortality from cancer in the Philippines, however, it has been difficult to develop chemotherapeutic agents due to developed resistance to existing ones. Angiogenesis is the formation of new blood vessels and is crucial for tumor growth and inhibiting it, termed antiangiogenesis, is a complementary treatment to cancer – now considered as the fourth modality. Carmona retusa is recognized by the Department of Health for its medicinal properties and previous studies where it showed antiangiogenic properties important for tumor suppression. This study was conducted to assess the antiangiogenic effects of C. retusa methanolic leaf extract to H69PR cell lines in ovo Duck Chorioallantoic Membrane Assay. The setups were composed of isotretinoin as positive control (PC) and C. retusa leaf extract in 5 mg/mL (TG5) and 10 mg/mL (TG10) concentrations. Immunohistochemical staining was used to assess tumor invasion, mitosis, necrosis (H&E); and microvascular density (desmin). Analysis of H&E sections showed squamous metaplasia in all treatment groups, and confirmed with chromogranin & synaptophysin stains. Tumor invasion was negative in TG10, while PC was negative for necrosis. Microvascular density (MVD) showed a decrease in average blood vessel formation in all treatment groups when compared to the negative control. To assess statistical significance of MVD, one-way ANOVA was performed and showed significant difference between treatment groups (p-value = 0.03), suggesting inhibition of angiogenesis in the PC, TG10, and TG5 groups. C. retusa leaf extract is as effective as the PC in inhibition of angiogenesis and at a higher concentration, may prevent tumor invasion, however, more investigation is needed.
Reference Key
persistent_1760653430_68f170767853c Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cadena, Gustav James Unarse
Journal Malay Journal
Year 2025
DOI
DOI not found
URL
https://animorepository.dlsu.edu.ph/etdb_bio/105
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.