Thromboxane A receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury.

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ID: 28449
2019
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Abstract
Sinusoidal obstruction syndrome (SOS) is a major complication of chemotherapy and hematopoietic stem cell transplantation. The early stage of SOS is characterized by liver sinusoidal endothelial cell (LSEC) injury accompanied by platelet aggregation. Thromboxane A (TxA) induces platelet aggregation through the thromboxane prostanoid (TP) receptor. In this study, we explored the role of TP signaling in a monocrotaline (MCT)-induced mouse model of SOS. Relative to wild-type (WT) mice, TP-deficient (TP) mice exhibited more severe MCT-liver injury, as indicated by elevated levels of alanine aminotransferase (ALT) and coagulative necrosis. Extensive accumulation of platelets in the liver was observed in both WT and TP mice. TP expression co-localized with CD31-positive LSECs. MCT treatment caused LSEC destruction, concomitant with elevated expression of matrix metalloproteinases (MMPs) and adhesion molecules in WT mice, and LSEC damage was further exacerbated in TP mice. Viability of isolated LSECs was lower in cells from TP mice, whereas mRNA levels of MMPs and adhesion molecules were higher; U46619, a TxA agonist, reduced these levels in WT mice. These data suggest that TP signaling has no effect on platelet accumulation during MCT-induced liver injury, but instead prevents injury by suppressing LSEC damage.
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Authors Otaka, Fumisato;Ito, Yoshiya;Inoue, Tomoyoshi;Ohkubo, Hirotoki;Nishizawa, Nobuyuki;Kojo, Ken;Betto, Tomohiro;Yamane, Sakiko;Narumiya, Shuh;Koizumi, Wasaburo;Majima, Masataka;
Journal toxicology and applied pharmacology
Year 2019
DOI
S0041-008X(19)30341-2
URL
Keywords Keywords not found

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