Histopathological evaluation of the effect of microspheres with different natural bioactive components (G. lucidum and I. graveolens) on osteoblastic activity in rats with experimental bone wounds
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2025
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Abstract
This study aimed to analyse the effects of microspheres containing G. lucidum and I. graveolens on bone healing in the alveolar socket after tooth extraction in Wistar rats. In this study, chitosan-coated and uncoated hydrogel microspheres were produced using sodium alginate-gelatine by dispersed phase gelling and crosslinking method in microsphere (MS) production. G. lucidum (GL) and I. graveolens (IG) extracts were entrapped in these microspheres. 126 healthy female rats were randomly divided into 7 different groups. The groups were named according to the microsphere placed in the alveolar socket after extraction. The effects of these microspheres on the healing of the alveolar bone in the groups were evaluated on the 7th day, the 14th day and the 28th day. Immunohistochemical analysis was used to assess bone healing. A statistically significant difference was observed between the negative control group and MS + Chitosan + IG group and between the MS group and MS + Chitosan + IG group in terms of bone formation percentages on the 28th day (p
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bayırlı2025histopathological
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| Authors | Ali Batuhan Bayırlı; S. Sezgin; E. Eren Belgin; Leyla Tekin; Hüseyin Çiçek; Aysegul Demirbas; Cankız Gizem Delibalta; Fatma Yilmaz |
| Journal | international journal of secondary metabolite |
| Year | 2025 |
| DOI |
10.21448/ijsm.1521929
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