Intestinal perforation after intravitreal low dose ranibizumab injection for the treatment of type 1 retinopathy of prematurity: A case report

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ID: 283424
2022
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Abstract
Purpose To report a newborn patient with gastrointestinal (GIS) perforation after intravitreal ranibizumab (RBZ) treatment. Case report The patient was born at 31 gestational week and hospitalized with the diagnosis of small for gestational age and prematurity. In the follow up he underwent GIS surgery due to necrotizing enterocolitis (NEC) and was diagnosed with retinopathy of prematurity (ROP). At 43 weeks of postmenstrual age, he developed intestinal perforation after 12 h of the second low-dose RBZ injection. According to our knowledge, this is the first report of GIS perforation due to low-dose intravitreal RBZ treatment in an infant with severe ROP. Conclusion The risk of GIS perforation should be taken into consideration during the application of intravitreal vascular endothelial growth factor antagonist agents, especially in newborns with previous GIS surgery and a history of NEC, and these patients should be carefully monitored for GIS complications.
Reference Key
rzayev2022intestinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Turkay Rzayev; H. Celiker; A. Aykut; K. Cerit; Ali Koyuncuer; Safak Gucyetmez; H. Ozdemi̇r; A. Memişoğlu; H. Bilgen; E. Ozek
Journal european journal of ophthalmology
Year 2022
DOI
10.1177/11206721221099249
URL
https://www.semanticscholar.org/paper/c9b496e48743e59325cf13838006d714ea130430
Keywords
treatment perforation retinopathy report intestinal dose ranibizumab case after type intravitreal injection prematurity:

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