The Diagnostic Value of Neutrophil and Monocyte Cell Population Data Obtained From a Hematology Analyzer in Neonatal Sepsis.

Clicks: 190
ID: 283422
2025
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Abstract
We aimed to investigate the diagnostic value of leukocyte cell population data (CPD) parameters obtained from an automated hematology analyzer to be able to use it in the diagnosis of neonatal sepsis. Our study was a retrospective and cross-sectional analysis. The neonates were classified into 3 groups: culture-positive sepsis (n = 20), clinical sepsis (n = 87), and control (n = 269). CPD parameters were determined during complete blood count (CBC) by volume-conductivity-scatter (VCS) technology with DxH 900 Coulter Cell Analyzer. Mean neutrophil volume (MNVNE), standard deviations of volumes of neutrophils (SDVNE), standard deviations of volumes of monocytes (SDVMO), and monocyte distribution width (MDW) were significantly increased in the culture-positive sepsis group compared with the clinical sepsis and control groups (P < .05). We have demonstrated the diagnostic utility of leukocyte CPD parameters, especially MNVNE, MDW, and their combination, for neonatal sepsis. These parameters are advantageous because they are obtained during routine CBC analysis without the need for additional blood collection and extra costs.
Reference Key
unlu2025the Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ozan Unlu; Sinem Gulcan Kersin; Tulay Cevlik; Nazmiye Unlu; H. Bilgen; E. Ozek; O. Sirikci; Goncagul Haklar
Journal La Clinica pediatrica
Year 2025
DOI
10.1177/00099228241309729
URL
https://www.semanticscholar.org/paper/d4c9dd6704afbee75ed51d7dfdcd7afea2f53df6
Keywords
data neonatal value population diagnostic hematology monocyte neutrophil from cell obtained analyzer sepsis.

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