Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy
Clicks: 85
ID: 282856
2012
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
25.2
/100
85 views
29 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #220 of 803 articles by views in arXiv
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 803 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Gold nanoparticles have been conceived as a radiosensitizer in cancer
radiation therapy, but one of the important questions for primary drug
screening is what size of gold nanoparticles can optimally enhance radiation
effects. Herein, we perform in vitro and in vivo radiosensitization studies of
4.8, 12.1, 27.3, and 46.6 nm PEG-coated gold nanoparticles. In vitro results
show that all sizes of the PEG-coated gold nanoparticles can cause a
significant decrease in cancer cell survival after gamma radiation. 12.1 and
27.3 nm PEG-coated gold nanoparticles have dispersive distributions in the
cells and have stronger sensitization effects than 4.8 and 46.6 nm particles by
both cell apoptosis and necrosis. Further, in vivo results also show all sizes
of the PEG-coated gold nanoparticles can decrease tumor volume and weight after
5 Gy radiations, and 12.1 and 27.3 nm PEG-coated gold nanoparticles have
greater sensitization effects than 4.8 and 46.6 nm particles, which can lead to
almost complete disappearance of the tumor. In vivo biodistribution confirms
that 12.1 and 27.3 nm PEG-coated gold nanoparticles are accumulated in the
tumor with high concentrations. The pathology, immune response, and blood
biochemistry indicate that the PEG-coated gold nanoparticles do not cause
spleen and kidney damages, but give rise to liver damage and gold accumulation.
It can be concluded that 12.1 and 27.3 nm PEG-coated gold nanoparticles show
high radiosensitivity, and these results have an important indication for
possible radiotherapy and drug delivery.
| Reference Key |
liang2012sizedependent
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Xiao-Dong Zhang; Di Wu; Xiu Shen; Jie Chen; Yuan-Ming Sun; Pei-Xun Liu; Xing-Jie Liang |
| Journal | arXiv |
| Year | 2012 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.