In vitro Demonstration of Cancer Inhibiting Properties from Stratified Self-Organized Micro-Discharge Plasma-Liquid Interface

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ID: 282844
2017
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Abstract
Experiments have revealed a nontrivial cancer-inhibiting capability of liquid media treated by the plasma jet capable of forming thinly stratified self-organized patterns at a plasma-liquid interface. A pronounced cancer depressing activity towards at least two kinds of human cancer cells, namely breast cancer MDA-MB-231 and human glioblastoma U87 cancer lines, was demonstrated. After a short treatment at the thinly stratified self-organized plasma-liquid interface pattern, the cancer inhibiting media demonstrate well pronounced depression and apoptosis activities towards tumor cells, not achievable without interfacial stratification of plasma jet to thin (of several um) current filaments, which therefore play a pivotal (yet still not completely clear) role in building up the cancer inhibition properties. Moreover, thinly stratified, self-organized interfacial discharge is capable to efficiently control the ROS and RNS concentrations in the cancer-inhibiting media, and in particular, abnormal ROS/RNS ratios not achievable in discharges which do not form stratified thin-filament patterns could be obtained. These results were explained in terms of interaction of thin plasma filaments of the self-organized pattern with gas and liquid, where the unusual interaction conditions (i.e., high surface-to-volume ratios etc.) cause accumulation of ROS, RNS and other species in unusual ratios and concentrations, thus forming potentially efficient anti-cancer cocktail. Our funding could be extremely important for handling the cancer proliferation problem, and hence, it should be brought to light to attract due attention of the researchers and explore the possible potential of this approach in tackling the challenging problem of high cancer-induced mortality and rising morbidity trends.
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keidar2017in Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhitong Chen; Shiqiang Zhang; Igor Levchenko; Isak I. Beilis; Michael Keidar
Journal arXiv
Year 2017
DOI
DOI not found
URL
http://arxiv.org/abs/1701.01655v1
Keywords
physics.med-ph physics.bio-ph physics.plasm-ph

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