Cancer Classification at the Crossroads

Clicks: 29
ID: 282840
2020
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Abstract
Internationally accepted classifications of malignant tumors, developed by the World Health Organization (WHO) and the Union for International Cancer Control (UICC), are based on the histotype, site of origin, morphologic grade, and spread of cancer throughout the body. The WHO classifications are the foundation of cancer diagnosis and the starting point for cancer management. Starting in 2000, the WHO classifications began to include biologic and molecular–genetic features. These developments are having a strong impact on cancer diagnosis and treatment, and this impact is amplifying, given the advances in cancer genomics. Molecular–genetic profiling can be used to refine existing classifications of tumors and, for a small but increasing number of cancers, even determine the treatment irrespective of histotype. Here I discuss how cancer classifications may change in the era of cancer genomics.
Reference Key
carbone2020cancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Carbone, Antonino
Journal Cancers
Year 2020
DOI
10.3390/cancers12040980
URL
https://doi.org/10.3390/cancers12040980
Keywords
Cancer classification crossroads

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