Cell-in-cell structures are involved in the competition between cells in breast cancer
Clicks: 51
ID: 282833
2021
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
15.0
/100
51 views
11 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #584 of 803 articles by views in arXiv
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 803 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Breast cancer is the most common cancer in women worldwide, and discovering
the biomarkers of this disease became so vital nowadays and Cell in Cell
structure could be one of them, and it may be used as an available proxy for
tumor malignancy. (CICs) are unusual in that keep morphologically healthy cells
within another cell. They are found in various human cancers and result from
active cell-cell interaction, and it has different kinds. In this study, we
analyzed the microarray data from GEO (GSE103865) to genetically evaluate CICs'
incidence in samples obtained from breast cancer patients to understand the
relationship between the rate of CIC and the prognosis of breast cancer. The
preprocessing was performed using R software. The DAVID website was used to
analyze gene ontology (GO) and Gene and Genome (KEGG) pathways. The
protein-protein interactions (PPIs) of the obtained DEGs were assessed using
the STRING website, and hub modules in Cytoscape and cytoHubba were screened.
According to the results from analyzing the 20 hub genes, we understood that
overexpression of our Top genes is effective in focal adhesion, ECM-receptor
interaction, platelet activation and PI3K-Akt signaling pathway, which shows
that changes in these pathways could be the reason the overexpression of CICs
in breast cancer. These data and research by many others have uncovered various
genes involved in CIC formation and have started to give us an idea of why they
are formed and how they could contribute to breast cancer
| Reference Key |
razi2021cellincell
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | S. Sajedeh Mousavi; Sara Razi |
| Journal | arXiv |
| Year | 2021 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.