Known Structure, Unknown Function: An Inquiry-based Undergraduate Biochemistry Laboratory Course
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ID: 282478
2015
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Abstract
Undergraduate biochemistry laboratory courses often do not provide students
with an authentic research experience, particularly when the express purpose of
the laboratory is purely instructional. However, an instructional laboratory
course that is inquiry- and research-based could simultaneously impart
scientific knowledge and foster a student's research expertise and confidence.
We have developed a year-long undergraduate biochemistry laboratory curriculum
wherein students determine, via experiment and computation, the function of a
protein of known three-dimensional structure. The first half of the course is
inquiry-based and modular in design; students learn general biochemical
techniques while gaining preparation for research experiments in the second
semester. Having learned standard biochemical methods in the first semester,
students independently pursue their own (original) research projects in the
second semester. This new curriculum has yielded an improvement in student
performance and confidence as assessed by various metrics. To disseminate
teaching resources to students and instructors alike, a freely accessible
Biochemistry Laboratory Education resource is available at
http://biochemlab.org.
| Reference Key |
mura2015known
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| Authors | Cynthia Gray; Carol W. Price; Christopher T. Lee; Alison H. Dewald; Matthew A. Cline; Charles E. McAnany; Linda Columbus; Cameron Mura |
| Journal | arXiv |
| Year | 2015 |
| DOI |
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