Enhancing the physiological characteristics of chimeric antigen receptor natural killer cells by synthetic biology.

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ID: 281763
2025
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Abstract
Chimeric antigen receptor natural Killer (CAR-NK) cells therapy represents a next-generation immunotherapeutic approach following CAR-T cells therapy, offering inherent "off-the-shelf" compatibility and mitigated off-tumor toxicity. Despite these advantages, clinical translation remains constrained by poor persistence and functional exhaustion in immunosuppressive tumor microenvironments (TME). This review examines recent advancements in synthetic biology aimed at enhancing the physiological characteristics of CAR-NK cells. By delineating the synergy between NK cells and synthetic biology toolkits, this work provides a roadmap for developing next-generation CAR-NK therapies capable of addressing solid tumor challenges while maintaining favorable safety profiles.
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Authors Ji, Shuochao; Jin, Cheng; Cui, Xinjiang
Journal Frontiers in immunology
Year 2025
DOI
10.3389/fimmu.2025.1592121
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Keywords
immunotherapy synthetic biology nk cells chimeric antigen receptor tme

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