ZnO Nanocomposites of and Extracts as Antiproliferative and Antimicrobial Agents.

Clicks: 118
ID: 281717
2022
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Abstract
Cancer and microbial infections constitute a major burden and leading cause of death globally. The development of therapeutic compounds from natural products is considered a cornerstone in drug discovery. Therefore, in the present study, the ethanolic extract and the fractions of and were evaluated for anticancer and antimicrobial activities. It was found that two fractions, JM and DC, exhibited promising anticancer and antimicrobial activities. The JM and DC fractions were further modified into ZnO nanocomposites, which were characterized by SEM, XRD, TGA, and EDX. It was noted that the synthesized nanocomposites displayed remarkable enhancement in cytotoxicity as well as antibacterial activity. Nanocomposite DC-ZnO NRs exhibited cytotoxicity with IC values of 16.4 ± 4 (HepG2) and 29.07 ± 2.7 μg/mL (HCT-116) and JM-ZnO NRs with IC values of 12.2 ± 10.27 (HepG2) and 24.1 ± 3.0 μg/mL (HCT-116). In addition, nanocomposites of DC (i.e., DC-ZnO NRs) and JM (i.e., JM-ZnO NRs) displayed excellent antimicrobial activity against with MICs of 2.5 and 1.25 μg/mL, respectively. Moreover, these fractions and nanocomposites were tested for cytotoxicity against normal fibroblasts and were found to be non-toxic. GC-MS analysis of the active fractions were also carried out to discover the possible phytochemicals that are responsible for these activities.
Reference Key
alghamdi2022zno Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alghamdi, Maha D; Nazreen, Syed; Ali, Nada M; Amna, Touseef
Journal Nanomaterials
Year 2022
DOI
10.3390/nano12040664
URL
Keywords
antibacterial anticancer nanocomposite dodonaea viscosa juniperus procera

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