Phytochemical study and evaluation of the cytotoxic properties of methanolic extract from Baccharis obtusifolia
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ID: 281716
2019
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Abstract
Some species of the Baccharis genus have been shown to possess important
biomedical properties, including cytotoxic activity. In this study, we examined
the cytotoxic effect of methanol extract from Baccharis obtusifolia
(Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma
(D-384), and breast (MCF-7). The methanolic extract displayed the largest
substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral
astrocytoma (D-384). Chromatographic purification of the B. obtusifolia
methanolic extract led to the isolation and identification of
5,4'-dihydroxy-7-methoxyflavone (1) and 5-hydroxy-7,4'-dimethoxyflavone (2)
compounds of the flavonoid type.
| Reference Key |
bailon-moscoso2019phytochemical
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|---|---|
| Authors | Juan Carlos Romero-Benavides; Gina C. Ortega-Torres; Javier Villacis; Sara L. Vivanco-Jaramillo; Karla I. Galarza-Urgiles; Natalia Bailon-Moscoso |
| Journal | arXiv |
| Year | 2019 |
| DOI |
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