Six new prenylated flavonoids from Dodonaea viscosa with anti-Zika virus activity.
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ID: 281698
2024
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Abstract
Six new prenylated flavonoids, named visconaeas A-F (1-6), and eleven known isopentenyl flavonoids (7-17) were isolated from Dodonaea viscosa (L.) Jacq. The structures of the separated compounds were determined through comprehensive spectral analysis and quantum chemical calculations. These compounds were tested for their anti-Zika virus and cytotoxicity activities. The results indicated that compound 4 showed low cytotoxicity and strong anti-Zika virus potential with EC 16.34 μM.
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| Authors | Pang, Wen-Hui; Wang, Bin-Bao; Huang, Yong-Xiang; Zhou, Xue-Mei; Wu, Xue-Wen; Zeb, Muhammad Aurang; Zhang, Rui-Han; Huang, Ning; Li, Xiao-Li; Zheng, Chang-Bo; Xiao, Wei-Lie |
| Journal | Fitoterapia |
| Year | 2024 |
| DOI |
10.1016/j.fitote.2024.106264
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