Different Strategies for Cancer Treatment: Mathematical Modeling

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ID: 281595
2006
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Abstract
We formulate and analyze a mathematical model describing immune response to avascular tumor under the influence of immunotherapy and chemotherapy and their combinations as well as vaccine treatments. The effect of vaccine therapy is considered as a parametric perturbation of the model. In the case of a weak immune response, neither immunotherapy nor chemotherapy is found to cause tumor regression to a small size, which would be below the clinically detectable threshold. Numerical simulations show that the efficiency of vaccine therapy depends on both the tumor size and the condition of immune system as well as on the response of the organism to vaccination. In particular, we found that vaccine therapy becomes more effective when used without time delay from a prescribed date of vaccination after surgery and is ineffective without preliminary treatment. For a strong immune response, our model predicts the tumor remission under vaccine therapy. Our study of successive chemo/immuno, immuno/chemo and concurrent chemoimmunotherapy shows that the chemo/immuno sequence is more effective while concurrent chemoimmunotherapy is more sparing.
Reference Key
osipov2006different Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors O. G. Isaeva; V. A. Osipov
Journal arXiv
Year 2006
DOI
DOI not found
URL
http://arxiv.org/abs/q-bio/0605046v3
Keywords
q-bio.cb

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