Exploring The Contribution of Innate Immune Cells to Breast Cancer Immunotherapy
Clicks: 53
ID: 281582
2023
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
15.6
/100
53 views
17 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #572 of 803 articles by views in arXiv
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 803 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Breast cancer is the leading type of cancer in women. About 10-15% of breast
cancers are triple-negative breast cancer (TNBC), a subtype with the worst
prognosis. Due to the lack of estrogen, progesterone and HER2 receptor
expression, chemotherapies have been the standard of care for decades.
Immunotherapy has emerged as promising for TNBC treatment. In 2020, the Food
and Drug Administration (FDA) granted approval to pembrolizumab in combination
with chemotherapy for patients with advanced triple-negative breast cancer.
However, only a subgroup of advanced TNBC patients live longer whose tumors
have a PD-L1 Combined Positive Score of at least 10 (CPS>=10). There is still
an unmet medical need to provide alternative treatment for the rest of
patients. Interestingly, a few of patients at UCSD Moores Cancer Center were
found to have had excellent responses to pembrolizumab despite low CPS scores
(termed Elite Responders). The hypothesis of this project is that there may be
an alternative immune response mechanism and/or crosstalk happening between the
innate and adaptive immune systems, especially in Natural Killer Cells and
Macrophages, that contributed to this unexpected excellent response. Our
procedure used ACDBio RNAscope Multiplex Fluorescence v2 method to spatially
analyze innate immune cells (Natural Killer cells and macrophages) and adaptive
immune cells (T-cells) in the Tumor Micro Environment. Our data demonstrated
increased tumor infiltration of innate immune cells (macrophage and Natural
Killer cells) in the Elite Responders. This conclusion indicated the joint
effort of two immune systems (innate and adaptive) which eventually led to
increased survival.
| Reference Key |
patel2023exploring
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Grace Sun; Sandip Patel |
| Journal | arXiv |
| Year | 2023 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.