Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Clicks: 135
ID: 281495
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #70 of 154 articles by views in Science

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 154 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
How farming protects against allergies People who grow up on dairy farms only rarely develop asthma or allergies. This is probably because as children, they breathe air containing bacterial components, which reduce the overall reactivity of the immune system. Schuijs et al. chronically exposed mice to bacterial endotoxin before they received an allergic stimulus. The protocol indeed protected them from developing an allergic response. Protection relied on a particular enzyme: A20. In humans, a variant of A20 correlates with increased susceptibility to asthma and allergy in children growing up on farms. Science, this issue p. 1106 Chronic exposure to bacterial endotoxin protects against allergy through the enzyme A20. Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with protection has remained elusive. Here we show that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite (HDM)–induced asthma. Endotoxin reduced epithelial cell cytokines that activate dendritic cells (DCs), thus suppressing type 2 immunity to HDMs. Loss of the ubiquitin-modifying enzyme A20 in lung epithelium abolished the protective effect. A single-nucleotide polymorphism in the gene encoding A20 was associated with allergy and asthma risk in children growing up on farms. Thus, the farming environment protects from allergy by modifying the communication between barrier epithelial cells and DCs through A20 induction.
Reference Key
schuijs2015farm Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Martijn J. Schuijs; M. Willart; Karl Vergote; D. Gras; K. Deswarte; M. Ege; Filipe Branco Madeira; R. Beyaert; G. van Loo; F. Bracher; E. von Mutius; P. Chanez; B. Lambrecht; H. Hammad
Journal Science
Year 2015
DOI
10.1126/science.aac6623
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.