An endotoxin-induced serum factor that causes necrosis of tumors.

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ID: 281482
1975
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Ranked #287 of 292 articles by views in Proceedings of the National Academy of Sciences of the United States of America

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Abstract
In studying "hemorrhagic necrosis" of tumors produced by endotoxin, it was found that the serum of bacillus Calmette--Guerin (BCG)-infected mice treated with endotoxin contains a substance (tumor necrosis factor; TNF) which mimics the tumor necrotic action of endotoxin itself. TNF-positive serum is as effective as endotoxin itself in causing necrosis of the sarcoma Meth A and other transplanted tumors. A variety of tests indicate that TNF is not residual endotoxin, but a factor released from host cells, probably macrophages, by endotoxin. Corynebacteria and Zymosan, which like BCG induce hyperplasia of the reticulo-endothelial system, can substitute for BCG in priming mice for release of TNF by endotoxin. TNF is toxic in vitro for two neoplastic cell lines; it is not toxic for mouse embryo cultures. We propose that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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Authors E. Carswell; L. Old; R. Kassel; S. Green; N. Fiore; B. Williamson
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 1975
DOI
10.1073/PNAS.72.9.3666
URL
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