Dunking into the Lipid Bilayer: How Direct Membrane Binding of Nucleoporins Can Contribute to Nuclear Pore Complex Structure and Assembly

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ID: 281360
2021
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Abstract
Nuclear pore complexes (NPCs) mediate the selective and highly efficient transport between the cytoplasm and the nucleus. They are embedded in the two membrane structure of the nuclear envelope at sites where these two membranes are fused to pores. A few transmembrane proteins are an integral part of NPCs and thought to anchor these complexes in the nuclear envelope. In addition, a number of nucleoporins without membrane spanning domains interact with the pore membrane. Here we review our current knowledge of how these proteins interact with the membrane and how this interaction can contribute to NPC assembly, stability and function as well as shaping of the pore membrane.
Reference Key
hamed2021dunkingcells Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hamed, Mohamed;Antonin, Wolfram;
Journal Cells
Year 2021
DOI
DOI not found
URL
https://www.mdpi.com/2073-4409/10/12/3601
Keywords
dermatology architecture cytology

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