residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites.

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ID: 281323
2025
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Abstract
This study elucidated the mechanisms underlying the immunoregulatory and gut-microbiota-modulating effects of residue polysaccharide (FVRP) using cyclophosphamide (CTX)-induced mouse models. FVRP supplementation alleviated CTX-induced intestinal damage and boosted antioxidant enzyme activity and cytokine secretion. Additionally, FVRP enhanced the diversity and total species richness of the gut microbiota, promoting the proliferation of beneficial bacteria (e.g., ), while reducing the abundance of CTX-derived bacteria ( and ). FVRP facilitates the accumulation of short-chain fatty acids. Untargeted metabolomic analyses of cecal content revealed that FVRP treatment notably restored the levels of 32 endogenous metabolites altered by CTX. Based on a pseudosterility mice model, fecal microbiota transplantation (FMT), and fecal filtrate transplantation (FFT), gut microbiota and associated metabolites were demonstrated to play a crucial role in the immunomodulatory and protective effects of FVRP against intestinal injury. In conclusion, FVRP exhibits significant potential as an immune enhancer and natural therapeutic agent for alleviating intestinal inflammatory conditions.
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Authors Yang, Yiting;Zhang, Yao;Zhang, Wenying;Lu, Kunpeng;Wang, Liping;Liu, Yanfang;Du, Linna;Yang, Jing;Guan, Lili;Ma, Hongxia;
Journal Journal of agricultural and food chemistry
Year 2025
DOI
10.1021/acs.jafc.4c12105
URL
Keywords
cyclophosphamide immunomodulation gut microbiota metabolomics intestinal injury flammulina velutipes residue polysaccharide

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