Rapid Mental Stress Evaluation Based on Non-Invasive, Wearable Cortisol Detection with the Self-Assembly of Nanomagnetic Beads.

Clicks: 85
ID: 281213
2025
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #66 of 94 articles by views in Biosensors

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The rapid and timely evaluation of the mental health of emergency rescuers can effectively improve the quality of emergency rescues. However, biosensors for mental health evaluation are now facing challenges, such as the rapid and portable detection of multiple mental biomarkers. In this study, a non-invasive, flexible, wearable electrochemical biosensor was constructed based on the self-assembly of nanomagnetic beads for the rapid detection of cortisol in interstitial fluid (ISF) to assess the mental stress of emergency rescuers. Based on a one-step reduction, gold nanoparticles (AuNPs) were functionally modified on a screen-printed electrode to improve the detection of electrochemical properties. Afterwards, nanocomposites of MXene and multi-wall carbon nanotubes were coated onto the AuNPs layer through a physical deposition to enhance the electron transfer rate. The carboxylated nanomagnetic beads immobilized with a cortisol antibody were treated as sensing elements for the specific recognition of the mental stress marker, cortisol. With the rapid attraction of magnets to nanomagnetic beads, the sensing element can be rapidly replaced on the electrode uniformly, which can lead to extreme improvements in detection efficiency. The detected linear response to cortisol was 0-32 ng/mL. With the integrated reverse iontophoresis technique on a flexible printed circuit board, the ISF can be extracted non-invasively for wearable cortisol detection. The stimulating current was set to be under 1 mA for the extraction, which was within the safe and acceptable range for human bodies. Therefore, based on the positive correlation between cortisol concentration and mental stress, the mental stress of emergency rescuers can be evaluated, which will provide feedback on the psychological statuses of rescuers and effectively improve rescuer safety and rescue efficiency.
Reference Key
li2025rapidbiosensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Junjie;Chen, Qian;Li, Weixia;Li, Shuang;Tan, Cherie S;Ma, Shuai;Hou, Shike;Fan, Bin;Chen, Zetao;
Journal Biosensors
Year 2025
DOI
140
URL
Keywords
Biosensor emergency medical rescue mental stress evaluation nanomagnetic beads reverse iontophoresis

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.