Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline.

主观认知下降中背侧楔前叶的汇聚性多模态影像异常

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ID: 281030
2024
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Ranked #34 of 37 articles by views in Journal of Alzheimer's disease : JAD

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Abstract
A range of imaging modalities have reported Alzheimer's disease-related abnormalities in individuals experiencing subjective cognitive decline (SCD). However, there has been no consistent local abnormality identified across multiple neuroimaging modalities for SCD.We aimed to investigate the convergent local alterations in amyloid-β (Aβ) deposition, glucose metabolism, and resting-state functional MRI (RS-fMRI) metrics in SCD.Fifty SCD patients (66.4±5.7 years old, 19 men [38%]) and 15 normal controls (NC) (66.3±4.4 years old, 5 men [33.3%]) were scanned with both [18F]-florbetapir PET and [18F]-fluorodeoxyglucose PET, as well as simultaneous RS-fMRI from February 2018 to November 2018. Voxel-wise metrics were retrospectively analyzed, including Aβ deposition, glucose metabolism, amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality(DC).The SCD group showed increased Aβ deposition and glucose metabolism (p < 0.05, corrected), as well as decreased ALFF, ReHo, and DC (p < 0.05, uncorrected) in the left dorsal precuneus (dPCu). Furthermore, the dPCu illustrated negative resting-state functional connectivity with the default mode network. Regarding global Aβ deposition positivity, the Aβ deposition in the left dPCu showed a gradient change, i.e., Aβ positive SCD > Aβ negative SCD > Aβ negative NC. Additionally, both Aβ positive SCD and Aβ negative SCD showed increased glucose metabolism and decreased RS-fMRI metrics in the dPCu.The dorsal precuneus, an area implicated in early AD, shows convergent neuroimaging alterations in SCD, and might be more related to other cognitive functions (e.g., unfocused attention) than episodic memory.
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Authors Li, Xuan-Yu;Yuan, Li-Xia;Ding, Chang-Chang;Guo, Teng-Fei;Du, Wen-Ying;Jiang, Jie-Hui;Jessen, Frank;Zang, Yu-Feng;Han, Ying;
Journal Journal of Alzheimer's disease : JAD
Year 2024
DOI
10.3233/JAD-231360
URL
Keywords
positron emission tomography functional magnetic resonance imaging alzheimer’s disease subjective cognitive decline precuneus

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