Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways

Clicks: 75
ID: 280141
2023
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Abstract Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bioactive nanoparticles to modify the brain microenvironment to achieve therapeutic benefits in a well‐characterized mouse model of Alzheimer's disease. The application of brain‐penetrating manganese dioxide nanoparticles significantly reduces hypoxia, neuroinflammation, and oxidative stress; ultimately reducing levels of amyloid β plaques within the neocortex. Analyses of molecular biomarkers and magnetic resonance imaging‐based functional studies indicate that these effects improve microvessel integrity, cerebral blood flow, and cerebral lymphatic clearance of amyloid β. These changes collectively shift the brain microenvironment toward conditions more favorable to continued neural function as demonstrated by improved cognitive function following treatment. Such multimodal disease‐modifying treatment may bridge critical gaps in the therapeutic treatment of neurodegenerative disease.
Reference Key
park2023brainpenetratingadvanced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Park, Elliya;Li, Lily Yi;He, Chunsheng;Abbasi, Azhar Z.;Ahmed, Taksim;Foltz, Warren D.;O'Flaherty, Regan;Zain, Maham;Bonin, Robert P.;Rauth, Andrew M.;Fraser, Paul E.;Henderson, Jeffrey T.;Wu, Xiao Yu;
Journal advanced science
Year 2023
DOI
DOI not found
URL
https://doi.org/10.1002/advs.202207238
Keywords
Medicine (General) Engineering (General). Civil engineering (General) Science Diseases of the blood and blood-forming organs agriculture history of scholarship and learning. the humanities social sciences philology. linguistics geology nuclear and particle physics. atomic energy. radioactivity astrophysics stratigraphy

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.