Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells

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ID: 278982
2018
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Abstract
Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines. The study aims to investigate whether ethanolic extract of Hedyotis corymbosa L. (EEH) performs anticancer properties by inhibiting migration and metastasis on breast cancer cells. Cytotoxic evaluation by using MTT assay was carried out to determine EEH effect on 4T1 breast cancer cells, meanwhile to investigate the treatment of EEH in migration and metastasis inhibitory effect, scratch wound healing assay and gelatin zymography were conducted in this study. The data showed that EEH possessed cytotoxic activity with IC50 value of 400 μg/mL.  Interestingly, migration inhibitory effect was shown up to 42 hours and the activity of MMP-9 was also decreased after the treatment with EEH. According to these findings, we suggest that Hedyotis corymbosa L. promotes another anticancer properties by inhibiting migration and metastasis towards breast cancer cells. Keywords : Hedyotis corymbosa L., cytotoxicity, migration, metastatic, 4T1 breast cancer cells
Reference Key
novitasari2018ethanoliciscc Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Novitasari, Dhania;Handayani, Sri;Jenie, Riris Istighfari;
Journal iscc (indonesian journal of cancer chemoprevention)
Year 2018
DOI
DOI not found
URL
https://ijcc.chemoprev.org/index.php/ijcc/article/view/199
Keywords
Pharmacy and materia medica Therapeutics. Pharmacology Biology (General) Medicine Science Other systems of medicine neoplasms. tumors. oncology. including cancer and carcinogens

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