Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

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ID: 278929
2024
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Abstract
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after myocardial ischemia that recovers without permanent damage. The relationship between IPC and myocardial stunning remains incompletely understood. This study aimed primarily to examine the effects of IPC on the relationship between ischemia duration, stunning, and infarct size in an ischemia-reperfusion injury model. Secondarily, this study aimed to examine to which extent the phosphoproteomic changes induced by IPC relate to myocardial contractile function.Methods and resultsRats were subjected to different durations of left anterior descending artery (LAD) occlusion, with or without preceding IPC. Echocardiograms were acquired to assess cardiac contraction in the affected myocardial segment. Infarction size was evaluated using triphenyl tetrazolium chloride staining. Phosphoproteomic analysis was performed in heart tissue from preconditioned and non-preconditioned animals. In contrast to rats without IPC, reversible akinesia was observed in a majority of the rats that were subjected to IPC and subsequently exposed to ischemia of 13.5 or 15 min of ischemia. Phosphoproteomic analysis revealed significant differential regulation of 786 phosphopeptides between IPC and non-IPC groups, with significant associations with the sarcomere, Z-disc, and actin binding.ConclusionIPC induces changes in phosphosites of proteins involved in myocardial contraction; and both accentuates post-ischemic myocardial stunning and reduces infarct size.
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Authors Elmahdy, Ahmed;Elmahdy, Ahmed;Espinosa, Aaron Shekka;Espinosa, Aaron Shekka;Kakaei, Yalda;Kakaei, Yalda;Pylova, Tetiana;Pylova, Tetiana;Jha, Abhishek;Jha, Abhishek;Zulfaj, Ermir;Krasnikova, Maryna;Krasnikova, Maryna;Al-Awar, Amin;Al-Awar, Amin;Sheybani, Zahra;Sheybani, Zahra;Sevastianova, Valentyna;Sevastianova, Valentyna;Berger, Evelin;Nejat, Amirali;Molander, Linnea;Molander, Linnea;Andersson, Erik Axel;Andersson, Erik Axel;Omerovic, Elmir;Omerovic, Elmir;Hussain, Shafaat;Hussain, Shafaat;Redfors, Björn;Redfors, Björn;Redfors, Björn;
Journal Frontiers in cardiovascular medicine
Year 2024
DOI
DOI not found
URL
https://www.frontiersin.org/articles/10.3389/fcvm.2024.1376367/full
Keywords
Education Medicine (General) Science surgery Diseases of the circulatory (Cardiovascular) system psychology business management. industrial management computer engineering. computer hardware electronic computers. computer science ethics nuclear and particle physics. atomic energy. radioactivity industrial psychology medical philosophy. medical ethics

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