Chimeric antigen receptor T‐cell therapy: Challenges and framework of outpatient administration

Clicks: 69
ID: 278430
2022
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Abstract Adoptive cellular therapy has made a landmark change within the treatment paradigm of several hematologic malignancies, and novel cellular therapy products, such as chimeric antigen receptor T‐cell therapy (CART), have demonstrated impressive efficacy and produced durable responses. However, the CART treatment process is associated with significant toxicities, healthcare resource utilization, and financial burden. Most of these therapies have been administered in the inpatient setting due to their toxicity profile. Improved toxicity management strategies and a better understanding of cellular therapy processes are now established. Therefore, efforts to transition CART to the outpatient setting are warranted with the potential to translate into enhanced patient quality of life and cost savings. A successful launch of outpatient CART requires several components including a multidisciplinary cellular therapy team and an outpatient center with appropriate clinical space and personnel. Telemedicine should be incorporated for closer monitoring. Additionally, clear criteria for admission upon clinical decompensation, a pathway for prompt inpatient transition, and clear toxicity management guidelines should be implemented. Effective education about cellular therapy and toxicity management is imperative, especially for the Emergency Department and Intensive Care Unit teams. Here, we have outlined the various logistical and clinical considerations required for the care of CART patients, which will aid centers to establish an outpatient CART program.
Reference Key
gatwood2022chimericejhaem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gatwood, Katie S.;Dholaria, Bhagirathbhai R.;Lucena, Mariana;Baer, Brittney;Savani, Bipin N.;Oluwole, Olalekan O.;
Journal eJHaem
Year 2022
DOI
DOI not found
URL
https://doi.org/10.1002/jha2.333
Keywords
chemistry Ecology microscopy Biology (General) Medicine Engineering (General). Civil engineering (General) Technology Electrical engineering. Electronics. Nuclear engineering Descriptive and experimental mechanics Science Diseases of the blood and blood-forming organs physics neurology. diseases of the nervous system neoplasms. tumors. oncology. including cancer and carcinogens electronics diseases of the genitourinary system. urology

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.