Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α.

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ID: 278380
2024
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Abstract
The cGAS-STING pathway appears to contribute to dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related to long COVID are still being investigated. In the present study, we evaluated the association of cGAS and STING gene expression levels and plasma IFN-α, TNF-α and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period. Quantification of gene expression was performed by real-time PCR, and cytokine levels were quantified by ELISA and flow cytometry. In acute COVID-19, cGAS, STING, IFN-α, TNF-α, and IL-6 levels were higher in patients with severe disease than in those with nonsevere manifestations (p < 0.05). Long COVID was associated with elevated cGAS, STING and IFN-α levels (p < 0.05). Activation of the cGAS-STING pathway may contribute to an intense systemic inflammatory state in severe COVID-19 and, after infection resolution, induce an autoinflammatory disease in some tissues, resulting in long COVID.
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Authors Queiroz, Maria Alice Freitas;Brito, Wandrey Roberto Dos Santos;Pereira, Keise Adrielle Santos;Pereira, Leonn Mendes Soares;Amoras, Ednelza da Silva Graça;Lima, Sandra Souza;Santos, Erika Ferreira Dos;Costa, Flávia Póvoa da;Sarges, Kevin Matheus Lima de;Cantanhede, Marcos Henrique Damasceno;Brito, Mioni Thieli Figueiredo Magalhães de;Silva, Andréa Luciana Soares da;Leite, Mauro de Meira;Viana, Maria de Nazaré do Socorro de Almeida;Rodrigues, Fabíola Brasil Barbosa;Silva, Rosilene da;Viana, Giselle Maria Rachid;Chaves, Tânia do Socorro Souza;Veríssimo, Adriana de Oliveira Lameira;Carvalho, Mayara da Silva;Henriques, Daniele Freitas;Silva, Carla Pinheiro da;Nunes, Juliana Abreu Lima;Costa, Iran Barros;Cayres-Vallinoto, Izaura Maria Vieira;Brasil-Costa, Igor;Quaresma, Juarez Antônio Simões;Falcão, Luiz Fábio Magno;Santos, Eduardo José Melo Dos;Vallinoto, Antonio Carlos Rosário;
Journal Scientific reports
Year 2024
DOI
4974
URL
Keywords
resistance xylem plant immunity xylella fastidiosa pierce’s disease

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