Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis

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ID: 278362
2020
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Abstract
Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T cells, and most studies have focused on the participation of T cells in the pathogenesis of this disease. Here we investigated the contribution of mononuclear phagocytes in the immunopathology observed in psoriatic patients. Significant increases in the levels of TNF, IL-1β, CXCL9, as well as the soluble forms of CD14 and CD163, were observed within the lesions of psoriatic patients compared to skin biopsies obtained from healthy individuals. Moreover, we found an association between the levels of CCL2, a monocyte attractant chemokine, and disease severity. In conclusion, our findings suggest a potential role for mononuclear phagocytes in the pathogenesis of psoriasis.
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costa2020mononuclearfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Costa, Mariana C.;Costa, Mariana C.;Paixão, Camilla S.;Viana, Débora L.;Rocha, Bruno de O.;Saldanha, Maíra;Mota, Lícia M. H. da;Machado, Paulo R. L.;Machado, Paulo R. L.;Pagliari, Carla;Oliveira, Maria de Fátima de;Arruda, Sergio;Carvalho, Edgar M.;Carvalho, Edgar M.;Carvalho, Edgar M.;Carvalho, Lucas P.;Carvalho, Lucas P.;Carvalho, Lucas P.;
Journal Frontiers in immunology
Year 2020
DOI
DOI not found
URL
https://www.frontiersin.org/article/10.3389/fimmu.2020.00478/full
Keywords
chemistry Infectious and parasitic diseases Biology (General) Medicine Immunologic diseases. Allergy food processing and manufacture agriculture plant culture bibliography. library science. information resources philosophy. psychology. religion philosophy (general) diplomatics. archives. seals

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