Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis.

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ID: 277494
2022
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Abstract
Ariboflavinosis is a pathological condition occurring as a result of riboflavin deficiency. This condition is treatable if detected early enough, but it lacks timely diagnosis. Critical symptoms of ariboflavinosis include neurological and visual manifestations, yet the effects of flavin deficiency on the retina are not well investigated. Here, using a diet induced mouse model of riboflavin deficiency, we provide the first evidence of how retinal function and metabolism are closely intertwined with riboflavin homeostasis. We find that diet induced riboflavin deficiency causes severe decreases in retinal function accompanied by structural changes in the neural retina and retinal pigment epithelium (RPE). This is preceded by increased signs of cellular oxidative stress and metabolic disorder, in particular dysregulation in lipid metabolism, which is essential for both photoreceptors and the RPE. Though many of these deleterious phenotypes can be ameliorated by riboflavin supplementation, our data suggests that some patients may continue to suffer from multiple pathologies at later ages. These studies provide an essential cellular and mechanistic foundation linking defects in cellular flavin levels with the manifestation of functional deficiencies in the visual system and paves the way for a more in-depth understanding of the cellular consequences of ariboflavinosis.
Reference Key
sinha2022riboflavinredox Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sinha, Tirthankar;Ikelle, Larissa;Makia, Mustafa S;Crane, Ryan;Zhao, Xue;Kakakhel, Mashal;Al-Ubaidi, Muayyad R;Naash, Muna I;
Journal Redox biology
Year 2022
DOI
102375
URL
Keywords
metabolism riboflavin retinal degeneration ariboflavinosis flavins rpe dystrophy retbindin

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