Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex.

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ID: 277455
2021
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Ranked #215 of 246 articles by views in Bioorganic & medicinal chemistry letters

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Abstract
The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.
Reference Key
duyar2021fluorenefluorenonebioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Duyar, Halil;Portakal, Hüseyin S;Yalçın, Ergin;Kanat, Beyza;Doluca, Osman;Seferoğlu, Zeynel;
Journal Bioorganic & medicinal chemistry letters
Year 2021
DOI
10.1016/j.bmcl.2021.127824
URL
Keywords
c-myc g-quadruplex fluorene fluorenone light-up probe

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