A Web-Based Method for the Identification of IL6-Based Immunotoxicity in Vaccine Candidates.

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ID: 277108
2023
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Abstract
Interleukin 6 (IL6) is a major pro-inflammatory cytokine that plays a pivotal role in both innate and adaptive immune responses. In the past, a number of studies reported that high level of IL6 promotes the proliferation of cancer, autoimmune disorders, and cytokine storm in COVID-19 patients. Thus, it is extremely important to identify and remove the antigenic regions from a therapeutic protein or vaccine candidate that may induce IL6-associated immunotoxicity. In order to overcome this challenge, our group has developed a computational tool, IL6pred, for discovering IL6-inducing peptides in a vaccine candidate. The aim of this chapter is to describe the potential applications and methodology of IL6pred. It sheds light on the prediction, designing, and scanning modules of IL6pred webserver and standalone package ( https://webs.iiitd.edu.in/raghava/il6pred/ ).
Reference Key
dhall2023amethods Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dhall, Anjali;Patiyal, Sumeet;Sharma, Neelam;Usmani, Salman Sadullah;Raghava, Gajendra P S;
Journal Methods in molecular biology (Clifton, N.J.)
Year 2023
DOI
10.1007/978-1-0716-3239-0_22
URL
Keywords
cytokines immunotoxicity vaccine candidate il6-inducing peptides therapeutic peptides

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