Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis.

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ID: 276856
2019
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Abstract
Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.
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stempniewicz2019potentialinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Agnieszka Stempniewicz, Piotr Ceranowicz, Zygmunt Warzecha
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Journal International journal of molecular sciences
Year 2019
DOI
1534
URL
Keywords
Cancer radiotherapy ghrelin oral mucositis chemotheraphy gut hormone obestatin

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