Comparison between body composition parameters and response to neoadjuvant chemotherapy by using pre-treatment PET CT in locally advanced breast cancer.

Clicks: 163
ID: 276847
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #2 of 2 articles by views in European journal of radiology open

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
To compare the adipose and muscle tissue areas in patients who responded differently to neoadjuvant chemotherapy.One hundred and eighty six patients diagnosed with breast cancer who underwent neoadjuvant chemotherapy between January 2015- October 2019 and were operated after the treatment were retrospectively included in the study. Pathological results were divided into five groups using the Miller-Payne grading systems. Grade 1 indicating no significant reduction in malignant cells; Grade 2: a minor loss of malignant cells (≤ 30 %); Grade 3: reduction in malignant cells between 30 % and 90 %; Grade 4: disappearance of malignant cells >90 %; Grade 5: no malignant cells identifiable. Pre-treatment PET CT scans were evaluated, and calculation of body composition parameters were performed on a single axial section passing through the L3 vertebrae. Spearman's correlation test was used to analyze the correlation between SAT, VAT, MT parameters and pathological responses.There was no strong correlation between the 5 groups separated according to neoadjuvant chemotherapy treatment response and tissue distributions. However, that there was a very low correlation found between superficial adipose tissue and pathological response (r=, 156).In conclusion, our results have provided a very low correlation between SAT and more than 30 % response. More research is required to evaluate the role of the body fat and muscle parameters in response to neoadjuvant chemotherapy in larger patient populations.
Reference Key
kizildag-yirgin2020comparisoneuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kizildag Yirgin, Inci;Has, Duygu;Arslan, Gozde;Aydin, Esra Cureoglu;Sari, Murat;Onder, Semen;Yasemin, Sanli;Cabioglu, Neslihan;Karanlik, Hasan;Tukenmez, Mustafa;Dursun, Memduh;Muslumanoglu, Mahmut;Ozmen, Vahit;
Journal European journal of radiology open
Year 2020
DOI
100286
URL
Keywords
Breast cancer computed tomography er, estrogen receptor adipose tissue bmi, body mass index ct, computed tomography asp, acylation-stimulating protein body composition parameter dcis, ductal carcinoma in situ her-2, human epidermal growth factor receptor-2 ihc, immunohistochemistry mp, miller -payne mt, muscle tissue nac, neoadjuvant chemotheraphy pai-1, plasminogen activator inhibitor-1 pet, ct positron-emission tomography-computed tomography pr, progesterone receptor sat, subcutaneous adipose tissue vat, visceral adipose tissue ypcr, pathological complete response

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.