Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs.

Clicks: 143
ID: 276843
2022
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Abstract
Colorectal cancer is one of the most common cancers diagnosed in the world. Chemotheraphy is one of the most common methods used for the pharmacological treatment of this cancer patients. Nevertheless, the adverse effect of chemotherapy is not optimized for improving the quality of life of people who are older, who are the most vulnerable subpopulation. This review presents recent updates regarding secondary metabolites derived from marine fungi and actinobacteria as novel alternatives for cytotoxic agents against colorectal cancer cell lines HCT116, HT29, HCT15, RKO, Caco-2, and SW480. The observed marine-derived fungi were from the species sp., sp., sp., sp., sp., and sp. Additionally, sp. and sp. are actinobacteria discussed in this study. Seventy one compounds reviewed in this study were grouped on the basis of their chemical structures. Indole alkaloids and diketopiperazines made up most compounds with higher potencies when compared with other groups. The potency of indole alkaloids and diketopiperazines was most probably due to halogen-based functional groups and sulfide groups, respectively.
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julianti2022secondarymarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Julianti, Elin;Abrian, Ikram Ammar;Wibowo, Marlia Singgih;Azhari, Muhammad;Tsurayya, Nadya;Izzati, Fauzia;Juanssilfero, Ario Betha;Bayu, Asep;Rahmawati, Siti Irma;Putra, Masteria Yunovilsa;
Journal Marine drugs
Year 2022
DOI
67
URL
Keywords
Cytotoxicity colorectal cancer actinobacteria fungi marine secondary metabolite

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