Image-guided radiotherapy in an orthotopic mouse model of rectal cancer.

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ID: 276121
2022
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Abstract
Radiobiology research in rectal cancer has been limited to cell lines, patient-derived organoids (PDOs), or xenografts. Here, we describe a protocol which recapitulates more efficiently the complex contributions of the tumor microenvironment. This approach establishes a preclinical mouse model of rectal cancer by intrarectal transplantation of genetically modified organoids into immunocompetent mice followed by precise image-guided radiotherapy (IGRT) of organoid-induced tumors. This model represents a useful platform to study the cellular and molecular determinants of therapy resistance in rectal cancer. For complete details on the use and execution of this protocol, please refer to Nicolas et al. (2022).
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nicolas2022imageguidedstar Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nicolas, Adele M;Pesic, Marina;Rödel, Franz;Fokas, Emmanouil;Greten, Florian R;
Journal STAR protocols
Year 2022
DOI
101749
URL
Keywords
Cancer health sciences model organisms

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