Comparative Analysis of the Hepatoprotective Potential of Coenzyme Q10 as a Preventive and a Therapeutic Agent in Statin-Induced Hepatotoxicity

Clicks: 223
ID: 275539
2022
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #1 of 5 articles by views in Molecular Medicine Communications

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Statins induce hepatotoxicity via reduced levels of Coenzyme Q10, inflammation, and oxidative stress. Coenzyme Q10 is anti-apoptotic and possesses an antioxidative potential and hence has been studied for its hepatoprotective potential. However, owing to the differing mechanisms of prevention of damage and its reversal, we hypothesize that coenzyme Q10 will have varying efficacy as a protective versus a therapeutic approach. An experimental study of 3 weeks was conducted in the department of Pharmacology on a sample of 35 mice, randomly divided into 7 groups.  Group 1 was used as a control. Group 2 received simvastatin 50mg/kg/day of simvastatin intraperitoneally (I/P). Group 3 received I/P 50mg/kg/day rosuvastatin. Group 4 received 50mg/kg/day of simvastatin+10mg/kg of coenzyme Q10. Group 5 received 50mg/kg/day of rosuvastatin+10mg/kg of coenzyme Q10 I/P. In group 6 simvastatin 50mg/kg & 7 rosuvastatin 50mg/kg was given for a week, and 10mg/kg of Coenzyme Q10 was started in the 2nd week and continued for 2 weeks. Hepatic damage was observed in groups 2,3,6 and 7 indicated by raised ALT levels of 320.4, 179.8, 301.4, and 186.8 and raised AST levels of 320, 196, 421.4, and 307.6. Bilirubin stayed within normal limits. Coenzyme Q10 prevents statin-induced liver damage but has no role as a therapeutic agent once the liver damage has already occurred.
Reference Key
jahan2022molecularcomparative Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sarwat Jahan;Sher Afghan Khan;Abdus Salam;Inayat Ur Rehman;Omer Farooq;Arsalan Afridi;
Journal Molecular Medicine Communications
Year 2022
DOI
25
URL
https://rootspress.org/journals/index.php/MMC/article/view/25
Keywords
oxidative stress hepatotoxicity hepatoprotection inflammation. inflation rate market index nyse nasdaq customer price index Children metabolic syndrome adolescents sugar sweetened beverage fruit juice drink sugar sweetened carbonated soft drink connectivity interdisciplinarity mediterranean archaeology naa pottery studies provenance determination cáncer; estilos de afrontamiento; psicooncología.cáncer estilos de afrontamiento psicooncología. human rights youth awareness constitutional protections

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.