One-Pot, Multicomponent, Diastereoselective, Green Synthesis of 3,4-Dihydro-2-benzo[][1,4]oxazine Analogues.
Clicks: 97
ID: 275498
2020
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
28.8
/100
96 views
12 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
A novel green and efficient catalyst-free, mild one-pot, multicomponent synthetic strategy has been developed to construct substituted 3,4-dihydro-2-benzo[][1,4]oxazine. This reaction proceeds via in situ formation of Schiff-base followed by base mediated alkylation with phenacyl bromide/substituted phenacyl bromide, finally leading to intramolecular cyclization to give a mixture of diastereomers with excellent diastereoselectivity (up to dr = 99:1), which were isolated as a single diastereomer in moderate to excellent yields (41-92%). Besides, this new versatile methodology provides a wide scope for the synthesis of different functionally substituted benzoxazine scaffolds and can be further exploited as building blocks for the synthesis of multifaceted molecular structures, especially for pharmaceutical applications.
| Reference Key |
kushwaha2020onepotthe
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Kushwaha, Narva Deshwar;Kushwaha, Babita;Karpoormath, Rajshekhar;Mahlalela, Mavela Cleopus;Shinde, Suraj Raosaheb; |
| Journal | The Journal of organic chemistry |
| Year | 2020 |
| DOI |
10.1021/acs.joc.0c00463
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.