Effects of KB-R9032, a new Na+/H+ Exchange Inhibitor, on Canine Coronary Occlusion/Reperfusion-Induced Ventricular Arrhythmias

Clicks: 164
ID: 275484
2005
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Star

Ranked #406 of 499 articles by views in Journal of pharmacological sciences

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 499 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
We investigated the effects of KB-R9032 (N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl) guanidine methanesulfonate), a new Na+/H+ exchange inhibitor, on a coronary artery occlusion/reperfusion-induced arrhythmia model in pentobarbital anesthetized dogs. KB-R9032 reduced the number of ventricular premature contractions seen during the coronary occlusion, while it did not alter the heart rate, mean blood pressure, or electrocardiographic parameters (PR, QRS, or QTc interval). KB-R9032 also decreased the incidence of fatal ventricular fibrillation during coronary artery occlusion and/or after reperfusion. These antiarrhythmic effects were observed not only in the pre-ischemic administration group, but also in the group given KB-R9032 at the 15th min of the 30-min occlusion. These findings support the view that Na+/H+ exchanger may play an important role in inducing coronary ischemia/reperfusion arrhythmias. This suggests that the use of Na+/H+ exchange inhibitors, such as KB-R9032, may be an effective clinical approach to suppress sudden cardiac death due to acute myocardial ischemia/reperfusion such as during coronary bypass surgery, cardiac valve surgery, or percutaneous transluminal coronary angioplasty. Keywords:: KB-R9032, Na+/H+ exchange, Ca2+ overload, arrhythmia ischemia, arrhythmia reperfusion
Reference Key
yamada2005effectsjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yamada, Chikaomi;Xue, YiXue;Chino, Daisuke;Hashimoto, Keitaro;
Journal Journal of pharmacological sciences
Year 2005
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1347861319321565
Keywords
chemistry Organic Chemistry Therapeutics. Pharmacology physics crystallography

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.