Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library
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ID: 275482
2016
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Abstract
The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.
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| Authors | Lenci, Elena;Innocenti, Riccardo;Biagioni, Alessio;Menchi, Gloria;Bianchini, Francesca;Trabocchi, Andrea; |
| Journal | molecules |
| Year | 2016 |
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