FlyWire: online community for whole-brain connectomics.

Clicks: 255
ID: 275004
2022
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Abstract
Due to advances in automated image acquisition and analysis, whole-brain connectomes with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated reconstructions will require many person-years of effort, due to the huge volumes of data involved. Here we present FlyWire, an online community for proofreading neural circuits in a Drosophila melanogaster brain and explain how its computational and social structures are organized to scale up to whole-brain connectomics. Browser-based three-dimensional interactive segmentation by collaborative editing of a spatially chunked supervoxel graph makes it possible to distribute proofreading to individuals located virtually anywhere in the world. Information in the edit history is programmatically accessible for a variety of uses such as estimating proofreading accuracy or building incentive systems. An open community accelerates proofreading by recruiting more participants and accelerates scientific discovery by requiring information sharing. We demonstrate how FlyWire enables circuit analysis by reconstructing and analyzing the connectome of mechanosensory neurons.
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dorkenwald2022flywirenature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dorkenwald, Sven;McKellar, Claire E;Macrina, Thomas;Kemnitz, Nico;Lee, Kisuk;Lu, Ran;Wu, Jingpeng;Popovych, Sergiy;Mitchell, Eric;Nehoran, Barak;Jia, Zhen;Bae, J Alexander;Mu, Shang;Ih, Dodam;Castro, Manuel;Ogedengbe, Oluwaseun;Halageri, Akhilesh;Kuehner, Kai;Sterling, Amy R;Ashwood, Zoe;Zung, Jonathan;Brittain, Derrick;Collman, Forrest;Schneider-Mizell, Casey;Jordan, Chris;Silversmith, William;Baker, Christa;Deutsch, David;Encarnacion-Rivera, Lucas;Kumar, Sandeep;Burke, Austin;Bland, Doug;Gager, Jay;Hebditch, James;Koolman, Selden;Moore, Merlin;Morejohn, Sarah;Silverman, Ben;Willie, Kyle;Willie, Ryan;Yu, Szi-Chieh;Murthy, Mala;Seung, H Sebastian;
Journal Nature Methods
Year 2022
DOI
10.1038/s41592-021-01330-0
URL
Keywords
lynch syndrome cancer predisposition hereditary colorectal cancer pold1 gene ppap syndrome

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